Preventive Effects of Low-Dose Interferon Alpha Oral Medication Against Shipping Fever in Thoroughbreds

Effect of Low-Dose Human Interferon-alpha on Shipping Fever of Thoroughbred Racehorses

To assess the effect of human interferon-alpha (IFNα) on shipping fever of Thoroughbred racehorses subjected to long-distance transportation, an IFNα preparation was orally administered to 48 horses three times (once daily, 3 successive days) before transportation (IFNα group). In the control group (25 horses), maltose was administered in the same way. These treatments induced no abnormal findi...

Effects of pre-shipping marbofloxacin administration on fever and blood properties in healthy Thoroughbreds transported a long distance

The present study evaluated the effects of single-dose marbofloxacin in protecting horses against fever associated with transportation using 48 healthy Thoroughbreds. All horses were premedicated with interferon-α (0.5 U/kg, sublingually, every 24 hr) for 2 days before transportation and on the day of transportation. Horses were randomly assigned to receive marbofloxacin (2 mg/kg, IV, once; MRF...

Preventive Inoculation against Enteric Fever

Low-dose oral use of interferon inhibits virally induced myocarditis.

Cytomegalovirus (CMV) infection has been associated with the development of myocarditis in humans. Our established mouse model for CMV myocarditis allows detailed investigation of the immunopathogenic mechanisms and therapies for cardiovascular disease. The type I interferons (IFN-alpha/beta) are part of the innate immune response to CMV infections. Previously, we have reported that daily treat...

Randomized Comparison of Low Dose versus High Dose Interferon-alpha in Chronic Myeloid Leukemia

Hanneke C. Kluin-Nelemans, Georgina Buck, Saskia le Cessie, Sue Richards, H. Berna Beverloo, J.H. Frederik Falkenburg, Tim Littlewood, Petra Muus, David Bareford, Hans van der Lelie, Anthony R Green, Klaas J. Roozendaal, Alison E Milne, Claire S. Chapman and Patricia Shepherd on behalf of the CML Working Group of the NCRI Adult Leukaemia Working Party and the HOVON trials group. Dept. Hematolog...